PhD scholarship in radiopharmaceutical chemistry

DTU Nutech
tirsdag 12 jun 18

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Frist 15. juli 2018
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Applications are invited from enthusiastic and talented individuals for a PhD scholarship in radiopharmaceutical chemistry at the Hevesy Laboratory at DTU Nutech (Risø Campus).

Project description
As a PhD candidate, you will enter the research program at the Hevesy Laboratory, where you will join the effort to develop new innovative drug delivery systems for diagnosing and treating cancer with radionuclides. At the Hevesy Laboratory, tracer and targeting systems are designed, radiolabeled and synthesized from scratch using organic and inorganic chemistry, radiochemistry and nanotechnology. Within this field, your work will mainly focus on the radionuclide astatine-211 and the radioactive isotopes of iodine. Astatine-211 is an up-and-coming alpha particle emitting radionuclide with great potential in cancer therapy.However, its chemistry and the tendency for astatinated molecules to undergo in vivo degradation and subsequent thyroid accumulation pose show-stopping challenges.

Using state-of-the-art nanoparticle and targeting technologies, as well as organic synthesis, you will work to overcome these challenges and develop clinically useful radiopharmaceuticals based on astatine-211. During the development, radioactive isotopes of iodine (I-125, I-124, I-131) will be employed as surrogates for astatine-211, due to their shared halogen chemistry as well as for their own diagnostic and therapeutic applications. The developed systems will be prepared at the Hevesy Laboratory as well as the School of Pharmacy at the University of Copenhagen. They will initially be tested in mouse models at the Panum Institute (Uni. of Copenhagen), followed by larger animals, and potentially translated to human subjects. The project will involve a significant amount of travelling, including at least one extended stay abroad (minimum 3 months).

About the department
The Hevesy Laboratory is a radiochemical and radiopharmaceutical division within the Center for Nuclear Technologies (DTU Nutech), with about 25 employees. The laboratory has a 16.5 MeV cyclotron equipped with a beam line for in-house production of radioisotopes, both for PET scans (18F, 64Cu, 89Zr, 52Mn) and internal radiotherapy. These radioisotopes are put to use in radioactive pharmaceuticals. The laboratory has chemistry and biology research laboratories and clean rooms, which feature state-of-the-art equipment for working with radioisotopes.

At present, the research group at the Hevesy laboratory consists of a young and dynamic multidisciplinary team, focusing on the development of new radioactive pharmaceuticals for diagnostics and therapy. Our research is heavily interdisciplinary and features multiple collaboration partners both nationally and internationally. In addition, our in-house GMP team produces radiopharmaceuticals for diagnostics and therapy, which are delivered to local hospitals as well as external collaborators. All scientific communication in the research group is done in English.

Qualifications
Candidates should have (or be about to obtain) a master's degree in chemical engineering, chemistry, pharmacy, or similar. Further, candidates should:

  • Have a solid foundation in chemistry, especially organic synthesis
  • Have an excellent command of English, both spoken and written
  • Have an excellent educational track record
  • Be driven, enthusiastic and highly ambitious
  • Have a positive and social mindset
  • Be passionate about science and pharmaceutical research
  • Be able to work independently if required to, but above all to feel comfortable communicating with other scientists of varying backgrounds and enjoy engaging in a team effort to achieve excellent results

Both practical and theoretical knowledge of nanomedicine, drug formulation, organometallic chemistry, inorganic chemistry, radioisotopes, pharmacology and physiology are considered advantageous.

Approval and Enrolment
The scholarships for the PhD degree are subject to academic approval, and the candidates will be enrolled in one of the general degree programs of DTU. For information about the general requirements for enrolment and the general planning of the scholarship studies, please see the DTU PhD Guide.

We offer
DTU is a leading technical university globally recognized for the excellence of its research, education, innovation and scientific advice. We offer a rewarding and challenging job in an international environment. We strive for academic excellence in an environment characterized by collegial respect and academic freedom tempered by responsibility.

Salary and appointment terms
The appointment will be based on the collective agreement with the Danish Confederation of Professional Associations. The allowance will be agreed upon with the relevant union. The period of employment is 3 years.

The primary place of work is the Hevesy Laboratory at DTU Nutech, Risø Campus in Roskilde.

You can read more about career paths at DTU here.

Further information
Further information may be obtained from Senior Scientist Andreas I. Jensen by e-mail or phone for questions and further details, atije@dtu.dk, +45 20126187.

Application
The application deadline is the 15 July 2018 (local time). Applications must be submitted as one PDF file containing all materials to be given consideration. To apply, please open the link "Apply online", fill out the online application form, and attach all your materials in English in one PDF file. The file must include:
  • Application Letter
  • Curriculum Vitae
  • Copy of your academic transcripts
  • Excel sheet with translation of grades to the Danish grading system (see guidelines and Excel spreadsheet here

Candidates may apply prior to obtaining their master's degree but cannot begin before having received it.

All interested candidates irrespective of age, gender, race, disability, religion or ethnic background are encouraged to apply.

DTU is a technical university providing internationally leading research, education, innovation and scientific advice. Our staff of 6,000 advance science and technology to create innovative solutions that meet the demands of society, and our 11,200 students are being educated to address the technological challenges of the future. DTU is an independent academic university collaborating globally with business, industry, government and public agencies.